General
Preferred name
DPAT
Synonyms
(±)-8-Hydroxy-DPAT hydrobromide ()
8-Hydroxy-DPAT hydrobromide ()
S(-)-8-HYDROXY-DPAT ()
8-hydroxy-DPAT ()
(R)-(+)-8-HYDROXY-DPAT ()
8-OH-DPAT,(-) ()
8-OH-DPAT,(+) ()
8-OH-DPAT ()
8-OH-DPAT hydrobromide ()
[3H]8-OH-DPAT ()
8-OH-DPAT (hydrobromide) ()
8-Hydroxy-DPAT (hydrobromide) ()
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide ()
8-OH-DPAT (8-Hydroxy-DPAT) ()
[3H]8-OH-DPAT ()
P&D ID
PD047959
CAS
76135-31-4
87394-87-4
78950-78-4
105558-30-3
Tags
available
biased GPCR ligand
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
3
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].
PRICE
46
DESCRIPTION
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
PRICE
35
DESCRIPTION
8-OH-Dpat (8-Hydroxy-DPAT) is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
DESCRIPTION
Highly selective alpha1 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective 5-HT1A serotonin receptor agonist
(LOPAC library)
DESCRIPTION
Selective 5-HT1A agonist. Also has moderate affinity for 5-HT7
(Tocriscreen Total)
DESCRIPTION
8-Hydroxy-DPAT hydrobromide is a selective 5-HT1A agonist with moderate affinity for 5-HT7 receptors (pKi = 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.
(TargetMol Bioactive Compound Library)
DESCRIPTION
8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor and a 5-HT7 receptor agonist as well. Studies showed that it exhibited antidepressant, anxiolytic and other properties.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
23
Axon Medchem Screening Library
BiasDB
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
High-quality chemical probes
Ki Database
LOPAC library
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
247.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
3.37
TPSA
23.47
Fraction CSP3
0.62
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
Primary Target
5-HT1A Receptors
MOA
Agonist
alpha-Adrenoceptor Antagonists
Member status
virtual
Target
5-HT1A agonist
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Solubility
DMSO Solubility: 49 mg/mL (198.07 mM)
Source data
